CBD Side Effects

Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is overall safe for consumption. Nonetheless, consumers should be made aware of any known potential drawbacks when consuming a health supplement product.

Below, we discuss findings from each recorded study and review the safety and known side effects of CBD.

1980: Study in Pharmacology

On January 3, 1980, Pharmacology published their findings from a study in which eight healthy volunteers and 15 patients with epilepsy consumed CBD daily for one month to assess its potential side effects.

Their reported conclusions were:

“All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.”

1986: International Journal of Neuroscience

In 1986, oral doses of cannabidiol ranging from 100mg to 600mg per day were given to five patients with dystonic movement disorders. In addition to recording specific benefits, this study also uncovered mild side effects of CBD such as hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation.

It is also noteworthy that during this study, two patients who were given CBD in doses over 300mg per day seemed to have aggravated Parkinson’s symptoms.

However, a 2014 study conducted by the Journal of Psychopharmacology concluded that CBD significantly improves the quality of life of those with Parkinson’s disease.

2006: Experimental Biology and Medicine

In 2006, a group of Argentinian scientists hypothesized that there are cannabinoid receptors in human salivary glands. In fact, their hypothesis was correct, which con- firmed a previous study which concluded that CBD users may experience the side effect commonly referred to as “cotton mouth.” They found that when CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth.

2011: Safety and Side Effects of Cannabidiol

Most recently, in 2011, a review on the safety and side effects of cannabidiol found that CBD might affect the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein.

Have you ever been told by a doctor or pharmacist not to drink or eat grapefruit while taking a prescription medication? In fact, grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of medications in the human body. If taken in large doses, CBD can inhibit the me- tabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system. This side effect is also why CBD counteracts some effects of THC.

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